Gene regulation by non-coding RNA
With the completion of the human genome project it became clear that the overwhelming majority of our genome does not encode proteins, yet is still actively transcribed, giving rise to hundreds of thousands of non-coding RNAs.
Since the function of most of these RNAs is unknown we study their impact on gene transcription using structural biology, biochemistry paired with next-generation sequencing and in vivo experiments.
Our work will advance applied research into tissue regeneration, cancer progression and will allow for a deeper understanding of aberrant gene expression in human disease.
We are grateful for funding from the following entities: